Duke went to Connecticut trying to make a statement, and instead ended up living a nightmare.
There are no unbeaten teams left in women's Division I basketball.
The win marked the first home-court victory for anyone in the series, which Geno Auriemma’s Huskies lead 6-3.
Maya Moore had 29 points and Tiffany Hayes 20 for UConn (21-1), which has now won 73 straight home games.
Kelly Faris added 14 points and while Stefanie Dolson had 12 rebounds for the Huskies, who started with a 23-2 run and then led 41-15 at the break.
Jasmine Thomas had 13 points including four 3-pointers to lead the Blue Devils (20-1), who shot 28.4 percent to the Huskies’ 57.4.
Connecticut won the rebound battle 43-20.
The teams will play in Durham next season.
Duke returns to ACC play on Thursday night with a home game against No. 18 Miami, coached by Duke alumna Katie Meier.