Jasmine Thomas had 16 points while Shay Selby came off the bench for a career-high 15, leading six players in double figures as No. 6 Duke demolished host Pittsburgh 93-55.
The Blue Devils, who got their most comfortable win so far this season, won the rebound battle 36-20.
Taneisha Harrison led the Panthers (2-2) with 16 points, followed by Brittaney Thomas with 12 and Shayla Scott with 10.
Duke’s next game is on Saturday at UNC Charlotte.