N.C. Central had all the points it needed at halftime.
Michael Johnson completed 10 of 21 passes for 115 yards and a touchdown while Tim Shankle (pictured) added 80 yards and another score on 21 carries, giving the Eagles an 18-10 victory over long-time rival and host Winston-Salem State at Bowman Gray Stadium.
The Eagles led 15-10 at the break.
Frankie Cardelle had a 24-yard field goal early in the second quarter and a 26-yarder midway through the fourth as Mose Rison's club improved to 3-7 with its second straight victory over the Rams (1-9).
It was NCCU's first win over a Division I (FCS) team this season, although WSSU has announced it will return to Division II in the fall.
NCCU leads the series 22-21.
Johnson's touchdown pass was a four-yarder to Saeed Abdul-Azeez, the Durham senior's only catch of the day.
The Eagles, who have won three of their last four games, conclude their season at home on Nov. 21 against Savannah State.